parameter

If you are using MariaDB/MySQL 5.5 and newer you should use several InnoDB Buffer Pool Instances for performance reasons.
Some rules to size InnoDB Buffer Pool instances are:

• One InnoDB Buffer Pool Instance should be at least 1 Gibyte in size (innodb_buffer_pool_size / innodb_buffer_pool_instances >= 1 Gib).
• InnoDB Buffer Pool Instances you can set equal to the number of cores of your machine.

The number of table definitions (SHOW CREATE TABLE\G) that can be stored in the table definition cache (table_definition_cache). If you have a large number of tables (> 400) in your database instance, you should consider a larger table definition cache to increase your database throughput and decrease your query latency.

The Table Open Cache (table_open_cache or old name table_cache) is a cache to store file handles for all threads. The actual value of cache entries can be seen with the global status of open tables (Open_tables).
Increasing table_open_cache increases the number of file descriptors (open_files_limit) that MySQL requires.

The InnoDB Flush Method has changed. This can have an impact on InnoDB write Performance.